The median nerve runs through a tight tunnel at the wrist, walled by bone below and a thick ligament above, sharing the space with nine tendons. The tunnel has no give, so anything that swells the contents raises the pressure against the nerve. Resting pressure is near zero; a symptomatic wrist runs ten times that, enough that bending the wrist pinches off the nerve's blood supply 1. At first the numbness comes only at night. Left alone, the insulation breaks down, then the nerve fibres themselves start to die. Early damage reverses fully once the pressure comes off. Late damage does not.
It hits three fingers, not five. Thumb, index, middle, and the thumb-side of the ring finger are median territory; a numb little finger is a different nerve at the elbow. Women get it about three times as often as men, mostly between forty and sixty, and the risk climbs with pregnancy, obesity 2, diabetes, or an underactive thyroid. The confirming test is a nerve conduction study: electrical pulses timed down the nerve across the wrist, which also rules out a pinched nerve in the neck masquerading as the same thing 3.
The order is splint, then injection, then surgery — and the further you have to go, the better the result tends to be.
First night in the splint, most people sleep through: the wrist stays straight, the pressure stays flat, and the 3 AM wake-up does not come. A steroid injection clears the numbness for weeks to a few months, then it creeps back. Surgical release divides the ligament over the tunnel in ten to fifteen minutes under local anaesthesia; by two months, eight or nine in ten people with milder disease report full or near-full resolution 5 6. A year out, the condition is over for the vast majority. The exceptions are the people who waited until the nerve was severely damaged; they keep some numbness and weakness for good 7.
The fine print — when to skip it, and what people get wrong
Typing and mouse use do not cause it; the evidence finds no link 8 9. Surgery is not a last resort either: for moderate-to-severe disease it is the right first answer 10. Wrist stretches help but never cure.
The main way this goes wrong is operating on the wrong problem: a neck nerve root or ulnar nerve can mimic it, which the nerve conduction study catches. The other is waiting until muscle wasting sets in, which recovers only partially 7.
Skin infection at the wrist: no injection or surgery until it clears. On blood thinners, coordinate surgery with your prescriber. In pregnancy, splint and wait, since most cases resolve after delivery 7.
- 1Werner RA, Andary M (2002). Carpal tunnel syndrome: pathophysiology and clinical neurophysiology. Clinical Neurophysiology. link
- 2Shiri R, Pourmemari MH, Falah-Hassani K, Viikari-Juntura E (2015). The effect of excess body mass on the risk of carpal tunnel syndrome: a meta-analysis of 58 studies. Obesity Reviews. link
- 3Jablecki CK, Andary MT, Floeter MK, Miller RG, Quartly CA, Vennix MJ, Wilson JR (2002). Practice parameter: Electrodiagnostic studies in carpal tunnel syndrome. Report of the American Association of Electrodiagnostic Medicine, American Academy of Neurology, and American Academy of Physical Medicine and Rehabilitation. Neurology. link
- 4Page MJ, Massy-Westropp N, O'Connor D, Pitt V (2012). Splinting for carpal tunnel syndrome. Cochrane Database of Systematic Reviews. link
- 5Atroshi I, Flondell M, Hofer M, Ranstam J (2013). Methylprednisolone injections for the carpal tunnel syndrome: a randomized, placebo-controlled trial. Annals of Internal Medicine. link
- 6Jarvik JG, Comstock BA, Kliot M, Turner JA, Chan L, Heagerty PJ, Hollingworth W, Kerrigan CL, Deyo RA (2009). Surgery versus non-surgical therapy for carpal tunnel syndrome: a randomised parallel-group trial. Lancet. link
- 7Padua L, Coraci D, Erra C, Pazzaglia C, Paolasso I, Loreti C, Caliandro P, Hobson-Webb LD (2016). Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurology. link
- 8Thomsen JF, Gerr F, Atroshi I (2008). Carpal tunnel syndrome and the use of computer mouse and keyboard: a systematic review. BMC Musculoskeletal Disorders. link
- 9Mediouni Z, Bodin J, Dale AM, Herquelot E, Carton M, Leclerc A, Fouquet N, Dumontier C, Roquelaure Y, Evanoff B, Descatha A (2015). Carpal tunnel syndrome and computer exposure at work in two large complementary cohorts. BMJ Open. link
- 10Graham B, Peljovich AE, Afra R, Cho MS, Gray R, Stephenson J, Gurman A, MacDermid J, Mlady G, Patel AT, Rempel D, Rozental TD, Salajegheh MK, Keith MW, Jevsevar DS, Shea KG, Bozic KJ (2016). The American Academy of Orthopaedic Surgeons Evidence-Based Clinical Practice Guideline on: Management of Carpal Tunnel Syndrome. Journal of Bone and Joint Surgery (American). link
დაკავშირებული სახელმძღვანელოში (5)
- — Frozen shoulder travels with carpal tunnel - both are soft-tissue conditions far more common in diabetes and low thyroid.
- — A mouse too far away and bent wrists at the keyboard are exactly the loads that aggravate the wrist nerve.
- — An underactive thyroid makes carpal tunnel more likely — worth checking if it's bilateral or unexplained.
- — Diabetes roughly doubles carpal tunnel risk — high blood sugar leaves the median nerve more vulnerable to compression.
- — Hand and wrist pain isn't always the nerve — overuse tendinopathies can mimic or sit alongside carpal tunnel.